What is AlzKB?

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AlzKB is a knowledge base summarizing what is known about Alzheimer's Disease drugs, genes, pathways, and other biological entities. The knowledge base is implemented as a graph database (using Memgraph), which offers many distinct advantages over traditional relational databases and non-graph formatted representations of biomedical knowledge.

You can find our GitHub repository here. The latest version of the graph database can be found in the Releases page. If you encounter any problems or would like to provide feedback, please open an issue on GitHub.

The knowledge in AlzKB is sourced from a large set of diverse, publicly available biomedical databases. Currently, AlzKB includes data from the following sources:

• AOP-DB (Adverse Outcome Pathway Database)
• Bgee^*
• Disease Ontology^*
• DisGeNET
• Drugbank
• EPA Computational Toxicology databases (DSSTox/AcTOR)
• Gene Ontology^*
• GWAS Catalog^*
• Hetionet
• Human Reference Protein Interactome Mapping Project^*
• LINCS L1000^*
• MeSH (NCBI Medical Subject Headings)^*
• NCBI Gene (Entrez Gene)
• Pathway Interaction Database^*
• PharmacotherapyDB^*
• PubChem
• Reactome^*
• SIDER^*
• TISSUES^*
• Uberon^*
• WikiPathways^*

^*included via Hetionet

Publications

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If you use AlzKB, please cite:

Romano J, Truong V, Kumar R, Venkatesan M, Graham B, Hao Y, Matsumoto N, Li X, Wang Z, Ritchie M, Shen L, Moore J

The Alzheimer’s Knowledge Base: A Knowledge Graph for Alzheimer Disease Research
J Med Internet Res 2024;26:e46777
DOI: 10.2196/46777
PMID: 38635981
URL: https://www.jmir.org/2024/1/e46777